RNA interference (RNAi) is the best way to effectively knock down gene expression to study protein function in a wide range of cell types. Traditional RNAi methods for gene knockdown in mammalian cells involved the use of synthetic RNA duplexes consisting of two unmodified 21mer oligonucleotides annealed together to form short/small interfering RNAs (siRNAs). Silencer® Select siRNA and Stealth RNAi™ siRNA improve upon these traditional duplexes by using proprietary chemical modifications to ensure better RNAi results.
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